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COVID-19 SCOPE Score to Predict Severe Respiratory Failure

 

Input
 

D-Dimer		mcg(DDU)/L mcg(DDU)/mL mcg(FEU)/L mcg(FEU)/mL mcg/mL mg(DDU)/L mg(FEU)/L mg/L ng(DDU)/mL ng(FEU)/mL
CRP		mg/L mg/dL nmol/L
Ferritin		mcg/L ng/mL pmol/L
IL-6		ng/L pg/mL

 
Result
 
Important: Inputs must be complete to perform calculation.

 

SCOPE Score		# count index logit none number points score
Decimal Precision   0 1 2 3

 

     
 
Include literature references: Yes   No

 

SCOPE Score Interpretation

 

0 to 5 points:	Severe progression less likely
6 to 12 points:	6-Fold increased risk of severe progression

 

 

 

Notes

• In this calculator, mcg is the abbreviation for micrograms.
• This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
• SCOPE: Severe COvid Prediction Estimate.
• In the Giamarellos-Bourboulis study^[1] a SCOPE score of 6 points correlated with a suPAR (soluble urokinase plasminogen activator receptor) concentration of 6 ng/mL, such that subjects with a suPAR ≥6 ng/mL had increased risk of severe respiratory failure.

 
Equations used
 

SCOPEScore = D-DimerFactor + CRPFactor + FerritinFactor + IL-6Factor

 

 

Calculation Details and Variables

• DDimerFactor is assigned values by this ordered logic:
  • If D-Dimer >0.9 mg/L DDimerFactor = 3
  • Else if D-Dimer >0.57 mg/L DDimerFactor = 2
  • Else if D-Dimer >0.4 mg/L DDimerFactor = 1
  • Else DDimerFactor = 0.
• CRPFactor is assigned values by this ordered logic:
  • If CRP >85 mg/L CRPFactor = 3
  • Else if CRP >45 mg/L CRPFactor = 2
  • Else if CRP >25 mg/L CRPFactor = 1
  • Else CRPFactor = 0.
• FerritinFactor is assigned values by this ordered logic:
  • If Ferritin >750 ng/mL FerritinFactor = 3
  • Else if Ferritin >450 ng/mL FerritinFactor = 2
  • Else if Ferritin >225 ng/mL FerritinFactor = 1
  • Else FerritinFactor = 0.
• IL6Factor is assigned values by this ordered logic:
  • If IL-6 >30 pg/mL IL6Factor = 3
  • Else if IL-6 >12 pg/mL IL6Factor = 2
  • Else if IL-6 >5 pg/mL IL6Factor = 1
  • Else IL6Factor = 0.

 

References

1. Giamarellos-Bourboulis EJ, Poulakou G, de Nooijer A, et al. Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure. Cell Rep Med. 2022 Feb 25;3(3):100560. PubMed ID: 35474750

 

Associated Medical Subject Headings [MeSH]
 

Biomarkers,   COVID-19,   Humans,   Prognosis,   Receptors,   Respiratory Insufficiency,   SARS-CoV-2,   Urokinase Plasminogen Activator

 

Associated Logical Observation Identifiers Names and Codes [LOINC]
 

Parameter	LOINC's and Suggested Units
D Dimer	48065-7 : mcg/mL      71427-9 : mcg/mL
CRP	1988-5 : mg/L      48421-2 : mg/L      76485-2 : nmol/L
Ferritin	2276-4 : ng/mL      24373-3 : ng/mL      20567-4 : ng/mL
IL 6	26881-3 : pg/mL      44322-6 : pg/mL

 
This material contains content from LOINC® (http://loinc.org). The LOINC table, LOINC codes, and LOINC panels and forms file are copyright © 1995-2014, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and available at no cost under the license at http://loinc.org/terms-of-use.