EBMcalc Logo
   INTRO    EQUATIONS    CRITERIA    DECISION    CONVERT    SPECIALTIES    REFS    SEARCH    NEW    CONTACT
 
  COVID-19 SCOPE Score to Predict Severe Respiratory Failure

 
Input
 
D-Dimer  
CRP  
Ferritin  
IL-6  

 
Result
 
 
SCOPE Score  
 
Decimal Precision  

 
     
 
Include literature references: Yes   No

 
  SCOPE Score Interpretation

 
0 to 5 points: Severe progression less likely
6 to 12 points: 6-Fold increased risk of severe progression

 
 

 
Notes
  • In this calculator, mcg is the abbreviation for micrograms.
  • This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
  • SCOPE: Severe COvid Prediction Estimate.
  • In the Giamarellos-Bourboulis study[1] a SCOPE score of 6 points correlated with a suPAR (soluble urokinase plasminogen activator receptor) concentration of 6 ng/mL, such that subjects with a suPAR ≥6 ng/mL had increased risk of severe respiratory failure.

 
Equations used
 
SCOPEScore = D-DimerFactor + CRPFactor + FerritinFactor + IL-6Factor

 

 
Calculation Details and Variables
  • DDimerFactor is assigned values by this ordered logic:
    • If D-Dimer >0.9 mg/L DDimerFactor = 3
    • Else if D-Dimer >0.57 mg/L DDimerFactor = 2
    • Else if D-Dimer >0.4 mg/L DDimerFactor = 1
    • Else DDimerFactor = 0.
  • CRPFactor is assigned values by this ordered logic:
    • If CRP >85 mg/L CRPFactor = 3
    • Else if CRP >45 mg/L CRPFactor = 2
    • Else if CRP >25 mg/L CRPFactor = 1
    • Else CRPFactor = 0.
  • FerritinFactor is assigned values by this ordered logic:
    • If Ferritin >750 ng/mL FerritinFactor = 3
    • Else if Ferritin >450 ng/mL FerritinFactor = 2
    • Else if Ferritin >225 ng/mL FerritinFactor = 1
    • Else FerritinFactor = 0.
  • IL6Factor is assigned values by this ordered logic:
    • If IL-6 >30 pg/mL IL6Factor = 3
    • Else if IL-6 >12 pg/mL IL6Factor = 2
    • Else if IL-6 >5 pg/mL IL6Factor = 1
    • Else IL6Factor = 0.

 
References
  1. Giamarellos-Bourboulis EJ, Poulakou G, de Nooijer A, et al. Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure. Cell Rep Med. 2022 Feb 25;3(3):100560. PubMed ID: 35474750 PubMed Logo

 
Associated Logical Observation Identifiers Names and Codes [LOINC]
 
Parameter LOINC's and Suggested Units
D Dimer 48065-7 : mcg/mL      71427-9 : mcg/mL      
CRP 1988-5 : mg/L      48421-2 : mg/L      76485-2 : nmol/L      
Ferritin 2276-4 : ng/mL      24373-3 : ng/mL      20567-4 : ng/mL      
IL 6 26881-3 : pg/mL      44322-6 : pg/mL      

 
This material contains content from LOINC® (http://loinc.org). The LOINC table, LOINC codes, and LOINC panels and forms file are copyright © 1995-2014, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and available at no cost under the license at http://loinc.org/terms-of-use.

 

 
Legal Notices and Disclaimer

 
All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.
 
EBMcalc is Copyright © 1998-2022 Foundation Internet    [Build 266662 v22.2]