Input
 

D-Dimer		mcg(DDU)/L mcg(DDU)/mL mcg(FEU)/L mcg(FEU)/mL mcg/mL mg(DDU)/L mg(FEU)/L mg/L ng(DDU)/mL ng(FEU)/mL
CRP		mg/L mg/dL nmol/L
Ferritin		mcg/L ng/mL pmol/L
IL-6		ng/L pg/mL

 
Result
 
Important: Inputs must be complete to perform calculation.

 

SCOPE Score		# count index logit none number points score
Decimal Precision   0 1 2 3

 

0 to 5 points:	Severe progression less likely
6 to 12 points:	6-Fold increased risk of severe progression

 

 

Data action

 
     
 
Include literature references: Yes   No

 

Notes

• In this calculator, mcg is the abbreviation for micrograms.
• This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
• SCOPE: Severe COvid Prediction Estimate.
• In the Giamarellos-Bourboulis study^[1] a SCOPE score of 6 points correlated with a suPAR (soluble urokinase plasminogen activator receptor) concentration of 6 ng/mL, such that subjects with a suPAR ≥6 ng/mL had increased risk of severe respiratory failure.

Calculation Details and Variables

• DDimerFactor is assigned values by this ordered logic:
  • If D-Dimer >0.9 mg/L, DDimerFactor = 3
  • Else if D-Dimer >0.57 mg/L, DDimerFactor = 2
  • Else if D-Dimer >0.4 mg/L, DDimerFactor = 1
  • Else DDimerFactor = 0.
• CRPFactor is assigned values by this ordered logic:
  • If CRP >85 mg/L, CRPFactor = 3
  • Else if CRP >45 mg/L, CRPFactor = 2
  • Else if CRP >25 mg/L, CRPFactor = 1
  • Else CRPFactor = 0.
• FerritinFactor is assigned values by this ordered logic:
  • If Ferritin >750 ng/mL, FerritinFactor = 3
  • Else if Ferritin >450 ng/mL, FerritinFactor = 2
  • Else if Ferritin >225 ng/mL, FerritinFactor = 1
  • Else FerritinFactor = 0.
• IL6Factor is assigned values by this ordered logic:
  • If IL-6 >30 pg/mL, IL6Factor = 3
  • Else if IL-6 >12 pg/mL, IL6Factor = 2
  • Else if IL-6 >5 pg/mL, IL6Factor = 1
  • Else IL6Factor = 0.

References

1. Giamarellos-Bourboulis EJ, Poulakou G, de Nooijer A, et al. Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure. Cell Rep Med. 2022 Feb 25;3(3):100560. PubMed ID: 35474750

Associated Medical Subject Headings [MeSH]
 

Biomarkers,   COVID-19,   Humans,   Prognosis,   Receptors,   Respiratory Insufficiency,   SARS-CoV-2,   Urokinase Plasminogen Activator

Associated Logical Observation Identifiers Names and Codes [LOINC]
 

Parameter	LOINC's and Suggested Units
D Dimer	48065-7 : mcg/mL      71427-9 : mcg/mL
CRP	1988-5 : mg/L      48421-2 : mg/L      76485-2 : nmol/L
Ferritin	2276-4 : ng/mL      24373-3 : ng/mL      20567-4 : ng/mL
IL 6	26881-3 : pg/mL      44322-6 : pg/mL

 
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