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COVID-19 FAPIC Score for Vaccine Induced Thrombotic Thrombocytopenia Syndrome

 

Input
 

Fibrinogen		g/L g/dL gm/L gm/dL mcg/dL mcg/mL mg% mg/dL mg/mL ng/mL
Age		mo yr
Platelets		#/mcL #/microL / nl /mcL /microL 10*3/uL 10*6/uL 10*6/uL 10E+9/L 10^3/microL K/mm3 K/uL Mill/mcl Million/ul Thous/mcL Thousand/uL X10E+09/L X10E+12/L cells/mcL cells/microL m/cmm thou/mcL x10(12)/L x10(3)/mcL x10(3)/microL x10(6)/L x10(6)/mcL x10(6)/microL x10(9)/L x1000/mm3 x10^12/L x10^3/mcL x10^3/microL x10^6/L x10^6/mcL x10^6/microL x10^9/L {cells}/uL
Intracranial Hemorrhage (ICH)	No (0)
	Yes (1)
Central Venous Thrombosis	No (0)
	Yes (1)

 
Result
 
Important: Inputs must be complete to perform calculation.

 

FAPIC Score		# count index logit none number points score

 

     
 
Include literature references: Yes   No

 

FAPIC Score Interpretation

 

0 points:	2.08% predicted mortality
1 point:	6.66% predicted mortality
2 points:	19.31% predicted mortality
3 points:	44.54% predicted mortality
4 points:	72.94% predicted mortality
5 points:	90.05% predicted mortality

 

 

 

Notes

• In this calculator, mcg is the abbreviation for micrograms.
• This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
• FAPIC: Fibrinogen, Age, Platelets, Intracerebral hemorrhage, Central venous thrombosis.

 
Equations used
 

FAPICScore = FibrinogenFactor + AgeFactor + PlateletsFactor + Intracranial Hemorrhage (ICH) + Central Venous Thrombosis

 

 

Calculation Details and Variables

• FibrinogenFactor is assigned values by this ordered logic:
  • If Fibrinogen <150 mg/dL FibrinogenFactor = 1
  • Else FibrinogenFactor = 0.
• AgeFactor is assigned values by this ordered logic:
  • If Age ≤60 yr AgeFactor = 1
  • Else AgeFactor = 0.
• PlateletsFactor is assigned values by this ordered logic:
  • If Platelets <25 x10^3/mcL PlateletsFactor = 1
  • Else PlateletsFactor = 0.
• Equation parameters such as Intracranial Hemorrhage (ICH), have two or more discrete values that may be used in the calculation. The numbers in the parentheses, e.g. (0), represent the values that will be used.

 

References

1. Hwang J, Park SH, Lee SW, et al. Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score. Eur Heart J. 2021 Sep 21:ehab592. PubMed ID: 34545400

 

Associated Medical Subject Headings [MeSH]
 

COVID-19,   COVID-19 Vaccines,   Humans,   Middle Aged,   SARS-CoV-2,   Thrombocytopenia,   Thrombosis,   Vaccination

 

Associated Logical Observation Identifiers Names and Codes [LOINC]
 

Parameter	LOINC's and Suggested Units
Fibrinogen	3255-7 : mg/dL      42772-4 : mg/dL      3256-5 : mg/dL
Age	21612-7 : yr      21612-7 : yr      21612-7 : years      30525-0 : Years old      30525-0 : yr      30525-0 : years
Platelets	777-3 : x10^9/L      26515-7 : x10(3)/mcL

 
This material contains content from LOINC® (http://loinc.org). The LOINC table, LOINC codes, and LOINC panels and forms file are copyright © 1995-2014, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and available at no cost under the license at http://loinc.org/terms-of-use.