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  COVID-19 FAPIC Score for Vaccine Induced Thrombotic Thrombocytopenia Syndrome

Intracranial Hemorrhage (ICH) No (0)

Yes (1)
Central Venous Thrombosis No (0)

Yes (1)

Important: Inputs must be complete to perform calculation.

FAPIC Score  

Include literature references: Yes   No

  FAPIC Score Interpretation

0 points: 2.08% predicted mortality
1 point: 6.66% predicted mortality
2 points: 19.31% predicted mortality
3 points: 44.54% predicted mortality
4 points: 72.94% predicted mortality
5 points: 90.05% predicted mortality


  • In this calculator, mcg is the abbreviation for micrograms.
  • This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
  • FAPIC: Fibrinogen, Age, Platelets, Intracerebral hemorrhage, Central venous thrombosis.

Equations used
FAPICScore = FibrinogenFactor + AgeFactor + PlateletsFactor + Intracranial Hemorrhage (ICH) + Central Venous Thrombosis


Calculation Details and Variables
  • FibrinogenFactor is assigned values by this ordered logic:
    • If Fibrinogen <150 mg/dL FibrinogenFactor = 1
    • Else FibrinogenFactor = 0.
  • AgeFactor is assigned values by this ordered logic:
    • If Age ≤60 yr AgeFactor = 1
    • Else AgeFactor = 0.
  • PlateletsFactor is assigned values by this ordered logic:
    • If Platelets <25 x10^3/mcL PlateletsFactor = 1
    • Else PlateletsFactor = 0.
  • Equation parameters such as Intracranial Hemorrhage (ICH), have two or more discrete values that may be used in the calculation. The numbers in the parentheses, e.g. (0), represent the values that will be used.

  1. Hwang J, Park SH, Lee SW, et al. Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score. Eur Heart J. 2021 Sep 21:ehab592. PubMed ID: 34545400 PubMed Logo

Associated Medical Subject Headings [MeSH]
         COVID-19,   COVID-19 Vaccines,   Humans,   Middle Aged,   SARS-CoV-2,   Thrombocytopenia,   Thrombosis,   Vaccination

Associated Logical Observation Identifiers Names and Codes [LOINC]
Parameter LOINC's and Suggested Units
Fibrinogen 3255-7 : mg/dL      42772-4 : mg/dL      3256-5 : mg/dL      
Age 21612-7 : yr      21612-7 : yr      21612-7 : years      30525-0 : Years old      30525-0 : yr      30525-0 : years      
Platelets 777-3 : x10^9/L      26515-7 : x10(3)/mcL      

This material contains content from LOINC® (http://loinc.org). The LOINC table, LOINC codes, and LOINC panels and forms file are copyright © 1995-2014, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and available at no cost under the license at http://loinc.org/terms-of-use.


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