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COVID-19 and the Systemic Immune-Inflammation Index (SII)

 

Input
 

Absolute Neutrophil Count		#/mcL #/microL / nl /mcL /microL 10*3/uL 10*6/uL 10*6/uL 10E+9/L 10^3/microL K/mm3 K/uL Mill/mcl Million/ul Thous/mcL Thousand/uL X10E+09/L X10E+12/L cells/mcL cells/microL m/cmm thou/mcL x10(12)/L x10(3)/mcL x10(3)/microL x10(6)/L x10(6)/mcL x10(6)/microL x10(9)/L x1000/mm3 x10^12/L x10^3/mcL x10^3/microL x10^6/L x10^6/mcL x10^6/microL x10^9/L {cells}/uL
Platelet Count		#/mcL #/microL / nl /mcL /microL 10*3/uL 10*6/uL 10*6/uL 10E+9/L 10^3/microL K/mm3 K/uL Mill/mcl Million/ul Thous/mcL Thousand/uL X10E+09/L X10E+12/L cells/mcL cells/microL m/cmm thou/mcL x10(12)/L x10(3)/mcL x10(3)/microL x10(6)/L x10(6)/mcL x10(6)/microL x10(9)/L x1000/mm3 x10^12/L x10^3/mcL x10^3/microL x10^6/L x10^6/mcL x10^6/microL x10^9/L {cells}/uL
Absolute Lymphocyte Count		#/mcL #/microL / nl /mcL /microL 10*3/uL 10*6/uL 10*6/uL 10E+9/L 10^3/microL K/mm3 K/uL Mill/mcl Million/ul Thous/mcL Thousand/uL X10E+09/L X10E+12/L cells/mcL cells/microL m/cmm thou/mcL x10(12)/L x10(3)/mcL x10(3)/microL x10(6)/L x10(6)/mcL x10(6)/microL x10(9)/L x1000/mm3 x10^12/L x10^3/mcL x10^3/microL x10^6/L x10^6/mcL x10^6/microL x10^9/L {cells}/uL

 
Result
 
Important: Inputs must be complete to perform calculation.

 

SII		# count index logit none number points score
Decimal Precision   0 1 2 3

 

     
 
Include literature references: Yes   No

 

SII Interpretation

 

<=618.8:	Lower criticality risk
>618.8:	Higher criticality risk

 

 

 

Notes

• This calculator represents findings from the literature referenced below. It is important to understand that these findings may not be representative of the experience in your local healthcare system.
• The SII should be calculated from blood counts at the time of hospital admission.
• For this calculation, note that the platelet count unit of measure is different from the white blood cell count units of measure.
• Subjects with an SII >618.8 had a 4.7 times higher mortality. This cut-off had sensitivity of 80% and specificity of 61.5%.^[1]

 
Equations used
 

SII = AbsoluteNeutrophilCount * PlateletCount / AbsoluteLymphocyteCount

 

 

References

1. Karaaslan T, Karaaslan E. Predictive Value of Systemic Immune-inflammation Index in Determining Mortality in COVID-19 Patients. J Crit Care Med (Targu Mures). 2022 Aug 12;8(3):156-164. PubMed ID: 36062039

 

Associated Logical Observation Identifiers Names and Codes [LOINC]
 

Parameter	LOINC's and Suggested Units
Absolute Neutrophil Count	751-8 : 10^3/microL      26499-4 : 10^3/microL      753-4 : 10^3/microL
Platelet Count	777-3 : x10^9/L      26515-7 : x10(3)/mcL
Absolute Lymphocyte Count	731-0 : x10^3/microL      26474-7 : x10^3/microL      732-8 : x10^3/microL

 
This material contains content from LOINC® (http://loinc.org). The LOINC table, LOINC codes, and LOINC panels and forms file are copyright © 1995-2014, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and available at no cost under the license at http://loinc.org/terms-of-use.