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FIB-4 Index, an Indirect Marker for Liver Fibrosis in Adults (2026 update)

 
The EBMcalc module FIB-4 Index, an Indirect Marker for Liver Fibrosis in Adults (2026 update) is available in EBMcalc Complete Edition.
 

 
This calculator yields the following results:
 
Equation parameters include:
 
References
  1. Vallet-Pichard A, Mallet V, Nalpas B, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. Hepatology. 2007; 46:32. PubMed ID: 17567829 PubMedLink
  2. McPherson S, Hardy T, Dufour JF, et al. Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis. Am J Gastroenterol. 2017; 112:740. PubMed ID: 27725647 PubMedLink
  3. Sterling RK, Patel K, Duarte-Rojo A, et al. AASLD Practice Guideline on blood-based noninvasive liver disease assessment of hepatic fibrosis and steatosis. Hepatology. 2025; 81:321. PubMed ID: 38489523 PubMedLink
  4. Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023; 77:1797. PubMed ID: 36727674 PubMedLink

 

 

 
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