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| PLASMIC Score for Estimating the Likelihood of Severe ADAMTS13 Deficiency in Adults with Suspected TTP |
The EBMcalc module PLASMIC Score for Estimating the Likelihood of Severe ADAMTS13 Deficiency in Adults with Suspected TTP is available in EBMcalc Complete Edition.
This calculator evaluates the following Clinical Criteria:
- Platelet count <30,000/microL
- One or more indicators of hemolysis:
Reticulocyte count (percentage) >2.5%; or
Haptoglobin undetectable; or
Indirect bilirubin >2.0 mg/dL [>34 mcmol/L] - No active cancer in the preceding year
- No history of solid organ or hematopoietic stem cell transplant
- Mean corpuscular volume (MCV) <90 femtoliters
- International normalized ratio (INR) <1.5
- Creatinine <2.0 mg/dL [<177 mcmol/L]
References
- Bendapudi PK, Hurwitz S, Fry A, et al. Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol. 2017 Apr;4(4):e157. PubMed ID: 28259520
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