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| Phenytoin Total Drug Level (Adjusted for Hypoalbuminemia and Renal Function) |
The EBMcalc module Phenytoin Total Drug Level (Adjusted for Hypoalbuminemia and Renal Function) is available in EBMcalc Complete Edition.
This calculator yields the following results:
- Phenytoin Adjusted
Equation parameters include:
- Phenytoin Measured
- Renal Fx
- Serum Albumin
References
- Martin E, Tozer TN, Sheiner LB, Riegelman S. The clinical pharmacokinetics of phenytoin. J Pharmacokinet Biopharm. 1977 Dec;5(6):579-96. PubMed ID: 599408
- Dasgupta A, Dennen DA, Dean R, McLawhon RW. Prediction of free phenytoin levels based on [total phenytoin]/[albumin] ratios. Potential errors with hypoalbuminemia. Am J Clin Pathol. 1991 Feb;95(2):253-6. PubMed ID: 1992618
- Kiang TK, Ensom MH. A Comprehensive Review on the Predictive Performance of the Sheiner-Tozer and Derivative Equations for the Correction of Phenytoin Concentrations. Ann Pharmacother. 2016 Apr;50(4):311-25. PubMed ID: 26825643
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