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Polycythemia Vera Diagnostic Criteria

Diagnostic:

2 Group A and 1 Group B and 0 Group C

Diagnostic:

2 Group A and 0 Group B and 2 Group C

Group A

Elevated RBC mass: Females: ≥32 mL/kg or Males: ≥36 mL/kg

Arterial O2 saturation ≥92%

Group B

Splenomegaly

Group C

Platelet count >400,000/microL

WBC count >12,000/microL in the absence of fever or infection

Leukocyte alkaline phosphatase (LAP) score >100 in the absence of fever or infection

B12 >900 pg/mL or serum unbound B12-binding capacity >2200 pg/mL

Interpretation

Data action

Include literature references: Yes No

References

Berk PD, Goldberg JD, Donovan PB, et al. Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Semin Hematol. 1986 Apr;23(2):132-43. PubMed ID: 3704665

Associated Medical Subject Headings [MeSH]

Associated ICD10-CM codes

D75.1

Secondary polycythemia

D45

Polycythemia vera

Associated ICD9-CM codes

238.4

Polycythemia vera

289.0

Secondary polycythemia

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