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Polycythemia Vera Diagnostic Criteria

 

	Diagnostic: 2 Group A and 1 Group B and 0 Group C
	Diagnostic: 2 Group A and 0 Group B and 2 Group C
Group A
		Elevated RBC mass: Females: ≥32 mL/kg or Males: ≥36 mL/kg
		Arterial O2 saturation ≥92%
Group B
		Splenomegaly
Group C
		Platelet count >400,000/microL
		WBC count >12,000/microL in the absence of fever or infection
		Leukocyte alkaline phosphatase (LAP) score >100 in the absence of fever or infection
		B12 >900 pg/mL or serum unbound B12-binding capacity >2200 pg/mL

 

 

 

 

Data action

 

     
 
Include literature references: Yes   No

 

References

1. Berk PD, Goldberg JD, Donovan PB, et al. Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Semin Hematol. 1986 Apr;23(2):132-43. PubMed ID: 3704665

 

Associated Medical Subject Headings [MeSH]
 

Acute Disease,   Age Factors,   Bloodletting,   Chlorambucil,   Combined Modality Therapy,   False Positive Reactions,   Follow-Up Studies,   Gastrointestinal Neoplasms,   Gout,   Hematocrit,   Humans,   Hydroxyurea,   Leukemia,   Phosphorus Radioisotopes,   Platelet Aggregation,   Platelet Count,   Polycythemia Vera,   Prospective Studies,   Pruritus,   Skin Neoplasms,   Thrombosis

 

Associated ICD10-CM Codes
 

	D75.1	Secondary polycythemia
	D45	Polycythemia vera

 

Associated ICD9-CM Codes
 

	238.4	Polycythemia vera
	289.0	Secondary polycythemia