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  Clinical Pulmonary Infection Score (CPIS)

Patient temperature

≥36.5 degrees C and ≤38.4 degrees C (0 points)

≥38.5 degrees C and ≤38.9 degrees C (1 point)

≥39 degrees C (2 points)

≤36 degrees C (2 points)

≥4,000/mm-3 and ≤11,000/mm-3 (0 points)

<4,000/mm-3 or >11,000/mm-3 (1 point)

<4,000/mm-3 or >11,000/mm-3 with ≥500 bands (2 points)
Tracheal secretions (0-4+ quantifications summed over 24 hours)

<14+ (0 points)

≥14+ (1 point)

≥14+ and purulent (2 points)

>240 or ARDS present (0 points)

≤240 or no ARDS present (2 points)
Chest X-Ray

No infiltrate (0 points)

Patchy or diffuse infiltrate (1 point)

Distinct infiltrate (2 points)
Quantitative pathogenic bacterial culture growth from tracheal aspirate

≤1+ or no growth (0 points)

>1+ (1 point)

>1+ and same bacteria seen on gram stain (2 points)

Important: Inputs must be complete to perform calculation.

Total Criteria Point Count:

  CPIS Interpretation

0 to 6 points: Pneumonia less likely
7 to 12 points: Pneumonia more likely


  Data action

Include literature references: Yes   No
  • The CPIS is used in the diagnosis of ventilator associated pneumonia.

  1. Pugin J, Auckenthaler R, Mili N, et al. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991 May;143(5 Pt 1):1121-9. PubMed ID: 2024824 PubMed Logo
  2. Rosbolt MB, Sterling ES, Fahy BG. The utility of the clinical pulmonary infection score. J Intensive Care Med. 2009 Jan-Feb;24(1):26-34. doi: 10.1177/0885066608327097. Epub 2008 Nov 19. Review. PubMed ID: 19019839 PubMed Logo
  3. Singh N, Rogers P, Atwood CW, et al. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):505-11. PubMed ID: 10934078 PubMed Logo


Associated ICD10-CM Codes
   I27.82Chronic pulmonary embolism
   I50.9Heart failure, unspecified
   J18.0Bronchopneumonia, unspecified organism

Associated ICD9-CM Codes
   482.9Bacterial pneumonia nos
   485Bronchopneumonia org nos
   481Pneumococcal pneumonia
   480.9Viral pneumonia nos


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