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  Osmolal Gap Calculator

The EBMcalc module Osmolal Gap Calculator is available in EBMcalc Complete Edition.

This calculator yields the following results:
Equation parameters include:
  1. Bhagat CI, Garcia-Webb P, Fletcher E, et al. Calculated vs measured plasma osmolalities revisited. Clin Chem. 1984 Oct;30(10):1703-5. PubMed ID: 6537784 PubMed Logo
  2. Purssell RA, Pudek M, Brubacher J, et al. Derivation and validation of a formula to calculate the contribution of ethanol to the osmolal gap. Ann Emerg Med. 2001; 38:653. PubMed ID: 11719745 PubMed Logo
  3. Carstairs SD, Suchard JR, Smith T, et al. Contribution of serum ethanol concentration to the osmol gap: a prospective volunteer study. Clin Toxicol (Phila). 2013 Jun;51(5):398-401. PubMed ID: 23641935 PubMed Logo
  4. Liamis G, Filippatos TD, Liontos A, Elisaf MS. Serum osmolal gap in clinical practice: usefulness and limitations. Postgrad Med. 2017 May;129(4):456-459. PubMed ID: 28306366 PubMed Logo
  5. Lepeytre F, Ghannoum M, Ammann H, et al. Formulas for Calculated Osmolarity and Osmolal Gap: A Study of Diagnostic Accuracy. Am J Kidney Dis. 2017 Sep;70(3):347-356. PubMed ID: 28578820 PubMed Logo
  6. Nguyen MK, Song L, Kao L, et al. Is the Osmolal Concentration of Ethanol Greater Than Its Molar Concentration? Front Med (Lausanne). 2020 Jan 8;6:306. PubMed ID: 31970159 PubMed Logo
  7. Khajuria A, Krahn J. Osmolality revisited--deriving and validating the best formula for calculated osmolality. Clin Biochem. 2005 Jun;38(6):514-9. PubMed ID: 15885229 PubMed Logo



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