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  SIRS Criteria: Systemic Inflammatory Response Syndrome

Respiratory Rate  
WBC Band Percent  

Important: Inputs must be complete to perform calculation.

SIRS Score  

Include literature references: Yes   No

  SIRS interpretation

0 to 1 point: SIRS not present
2 to 4 points: SIRS present



Equations used
SIRSScore = TempFactor + PulseFactor + WBCFactor + RespFactor


Calculation Details and Variables
  • TempFactor is assigned values by this ordered logic:
    • If Temperature >38 degC TempFactor = 1
    • Else if Temperature ≥36 degC TempFactor = 0
    • Else TempFactor = 1.
  • PulseFactor is assigned values by this ordered logic:
    • If Pulse >90 beats/min PulseFactor = 1
    • Else PulseFactor = 0.
  • The RespFactor is set to 1 when the RespiratoryRate is >20 breaths/min or the PaCO2 is <20 mmHg. Otherwise the RespFactor is set to 0.
  • The WBCFactor is set to 1 if the WBC is <4,000 #/microL, the WBC >12,000 #/microL, or the WBCBandPercent is >10%. Otherwise the WBCFactor is dset to 0.

  1. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992 Jun;101(6):1644-55. PubMed ID: 1303622 PubMed Logo

Associated Medical Subject Headings [MeSH]
         Critical Care,   Humans,   Medical,   Multiple Organ Failure,   Pulmonary Medicine,   Sepsis,   Septic,   Severity of Illness Index,   Shock,   Societies,   Syndrome,   Terminology as Topic

Associated Logical Observation Identifiers Names and Codes [LOINC]
Parameter LOINC's and Suggested Units
Temperature 8329-5 : degC      8310-5 : degC      8331-1 : degC      8332-9 : degC      8333-7 : degC      8328-7 : degC      75539-7 : degC      
Pulse 8867-4 : beats/min      8893-0 : beats/min      8890-6 : beats/min      8889-8 : beats/min      68999-2 : beats/min      76282-3 : beats/min      69000-8 : beats/min      69001-6 : beats/min      
Respiratory Rate 9303-9 : breaths/min      9279-1 : breaths/min      76170-0 : breaths/min      19840-8 : breaths/min      
PaCO2 2019-8 : mmHg      34705-4 : mmHg      
WBC 6690-2 : #/microL      
WBC Band Percent 764-1 : %      35332-6 : %      26508-2 : %      

This material contains content from LOINC® (http://loinc.org). The LOINC table, LOINC codes, and LOINC panels and forms file are copyright © 1995-2014, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and available at no cost under the license at http://loinc.org/terms-of-use.

Associated ICD10-CM Codes
   J96.90Respiratory failure, unspecified, unspecified whether with hypoxia or hypercapnia
   J96.00Acute respiratory failure, unspecified whether with hypoxia or hypercapnia
   A41.9Sepsis, unspecified organism
   I50.9Heart failure, unspecified
   I50.9Heart failure, unspecified
   N19Unspecified kidney failure

Associated ICD9-CM Codes
   584.9Acute renal failure nos
   586Renal failure nos
   428.9Heart failure nos
   038.9Septicemia nos
   518.81Acute respiratry failure


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